I’ve heard of people doing this. I guess it all depends on what you want to accomplish… BizTalk is not “officially” supported on non-Microsoft VW’s. You’d need to check the KB for the exact details. And performance would take a hit.
So, if you didn’t need a high performing and mission critical solution, it would be fine.
It’s not something I’d really go and suggest or even be too thrilled about having to work with. I don’t even do Dev work on VM unless the client absolutely demands it.