BizTalk can be installed using command line such as this:

Setup.exe /quiet /addlocal all /IGNOREDEPENDENCIES /INSTALLDIR D:\program files\Microsoft BizTalk Server 2010 /s D:\Install\biztalk2010/configBiztalk2010.xml

But we had an issue with the INSTALLDIR flag. Using the above path, the installation was failing with an error “Unable to load xml file: c:\users\insUser\AppData\Local\Temp\EBZ39051.tmp\1033\Autorun.xml”

After quite a lot of investigation the developer realised that the INSTALLDIR path with spaces in the name was the culprit. Instead, the path should be its DOS short name. In order to do that, do the following:

1) Create the destination folder using the commande MKDIR on the destination drive
2) Get the DOS path using the command DIR /X from the destination drive
3) Run again using now the command such as in this example using the new path: “Setup.exe /quiet /addlocal all /IGNOREDEPENDENCIES /INSTALLDIR D:\PROGRA~2\MICROS~2\ /s D:\Install\biztalk2010/configBiztalk2010.xml”. It should work fine!

Vincent Rouet, CODit