This has happened now three times to me, and I just received an email from a friend about this.

When you install the HL7 accelerator on a 64bit machine, you need to create a 32bit host; as the HL7 DASM and ASM are 32bit only.

A hint as to what kind of host needs to be set up is found in the root drive:

To do this, you need to create a 32 bit host:

Create the Host Instance:

Create a new send and receive handler using the new 32 bit host that is just created:

Which ends up looking like this:

And now to change the actual receive or send port to use the 32 bit host instance