Probably the easiest method to configure is file drop. You can use System.IO and the built in file and folder controls to reach them. Now you either create XML or some flat file type to package your data and drop it to your Receive Location folder. You can read the response from a send port folder.
That said, I agree with John D. on the way to get started. There are also now a few good books on the subject, and a plethora of integration options, including Web Services, HTTP, SQL and Oracle DB.
Please, tell us more about what you are trying to accomplish. It sounds like you want to find a quick way to understand BizTalk. The best way is to find a pattern you like or that makes sense and create your own version. Look for BizTalk 2006 Recipes: A Problem-Solution Approach