There are the main sources of the information of the subj:

The blog of the BizTalk Performance
http://blogs.msdn.com/biztalk_performace_explorer/default.aspx
The articles in the MSDN:
“BizTalk Server 2006: Managing a Successful Performance Lab ” http://msdn2.microsoft.com/en-us/library/aa972201.aspx
“BizTalk Server 2004: Performance Tuning for Low Latency Messaging”http://msdn2.microsoft.com/en-us/library/aa475435.aspx
The BizTalk Help articles:
Performance and Capacity Planning”
Identifying Bottlenecks in the BizTalk Tier” (the list of the BizTalk System Performance Counters)

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