Check your DTC configurations. Use the following tools
DTCTester – Most BizTalk Server runtime operations require Microsoft Distributed Transaction Coordinator (MSDTC) support to ensure that the operations are transactionally consistent. If MSDTC transaction support is not available, then the associated BizTalk Server runtime operations cannot proceed. Use the DTCTester tool to verify distributed transaction support across firewalls or against networks. The DTCTester utility uses ODBC to verify transaction support against a SQL Server database and therefore requires that SQL Server is installed on one of the computers being tested. For more information about DTCTester
Use the DTCPing tool to verify distributed transaction support across firewalls or against networks. The DTCPing tool must be installed on both the client and server computers and is a good alternative to the DTCTester utility when SQL Server is not installed on either computer. For more information about using DTCPing to verify distributed transaction support,
Read KB Article –
http://support.microsoft.com/kb/306843
Still you are getting the issue please let me know
Nandika