You will want to export the BizTalk application’s binding files, make the changes and then import them back in. Or, you can modify them directly through the BizTalk Admin Console (BTS 2006/R2).
If you have a lot of repeating paths, exporting them and performing a Find and Replace may be the quickest method. YOu will need to import the binding files after the changes.
Check this document for more info:
http://technet.microsoft.com/en-us/library/aa560753.aspx
Edit: Sorry, I just realized this was in the 2004 forum. You will want to work with the binding files directly …IMO